منابع مشابه
بررسی ارتباط پلی‌مورفیسم (rs1800872A/C) ژن اینترلوکین 10 با ابتلا به عفونت مزمن هپاتیت B
Background and Aim: Cytokines are believed to play an important role in the regulation of cellular immune response in hepatitis B virus infection. Interleukin 10 is a member of cytokine family. The overall expression of these molecules is mainly controlled by single nucleotide polymorphisms at specific sites on the promoter region of the Interleukin 10 gene. The aim of this study was to a...
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Background & Objective: Cytokines are immune system factors known to play a key role in both HCV clearance and the development of infection the impact of host genetic factors on the clinical outcome of HCV infection has not been elucidated. On the other hand, the impact of Genetic changes like Single nucleotide polymorphisms on expression rate and function of Cytokine is under study. The aim ...
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Background: Tumor necrosis factor-beta or lymphotoxin-alpha (LT-α), IL-4 and IL-10 are determining factors in immunity against BCG. Allelic polymorphisms in the regulatory regions of their genes affect the rate of cytokine production and therefore, the host’s ability in BCG containment. Objective: To study the prevalence of –590 (C/T) and –592 (C/A) allelic distribution of IL-4 and IL-10 promo...
متن کاملThe Role of Interleukin 1β Gene Polymorphism in Gastric Cancer in North-eastern Iran
Background and Objective: Host genetic factors such as cytokine gene polymorphisms as well as Helicobacter pylori (H. pylori) infection have been found to be associated with gastric cancer risk . Interleukin 1 is a pro-inflammatory cytokine involved in H. pylori-induced gastric inflammation. Therefore, w...
متن کاملAssociation between IL6 gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population
Interleukin-6 (IL6) is encoded by the IL6 gene in human and acts as pro-inflammatory cytokine and an anti-inflammatory cytokine. Recent studies established that IL6 substantially contribute in the diagnosed of systemic inflammation for the patients suffering from lung diseases such as chronic obstructive pulmonary disease (COPD). Thereof, this work aimed to investigate the prot...
متن کاملTh1 and Th2 Cytokine Gene Polymorphism in Iranian Patients with Chronic Myelogenous Leukemia
Background:It has been hypothesized that genetic factors other than histocompatibility disparity may play a role in predisposition to developing Chronic Myelogenous Leukemia (CML). In this regard, Th1 and Th2 cytokines and their gene polymorphism seems to be important. Overall expression and secretion of cytokines is dependent, at least in part, on genetic polymorphism (nucleotide variations) w...
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تاریخ انتشار 2014